RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
PDXK
RNA ID
RNA Type
circRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; bioinformatic analysis
Target
NA
Pathway
NA
PubMed ID
Title
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation
Year
2017
Function
"Compared with the normal HSC, 179 circRNAs were found to be up-regulated and 630 circRNAs were down-regulated in irradiated HSC (fold change >=2.0 and P<0.05). Six dysregulated circRNAs selected randomly were successfully verified by qRT-PCR. Bioinformatic analyses indicated that dysregulated circRNA might be involved in the cell response to irradiation and biological processes of hepatic fibrosis. Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation."